For adult patients with moderately to severely active UC or CD when other therapies have not worked well enough or cannot be tolerated.
Infusion Center Locator
Find infusion centers where your patients may be able to receive Entyvio.
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The data provided in connection with the Entyvio Infusion Center Locator is for informational purposes only. No fees or other remuneration have been or will be exchanged for an infusion center's inclusion in this database. Takeda Pharmaceuticals U.S.A., Inc. is not affiliated with, and inclusion in this database does not represent an endorsement of, recommendation for, or referral to the infusion centers listed in this database. Likewise, participating infusion centers do not necessarily endorse the use of any Takeda Pharmaceuticals U.S.A., Inc. products.
Takeda Pharmaceuticals U.S.A., Inc. makes no representations as to whether any of the infusion sites of care participating in this database are covered by particular healthcare plans or insurers, if at all. Insurance verification is solely the responsibility of the provider. Providers are responsible for compliance with state and federal laws regulating physician referrals, such as anti-kickback laws, the Stark law, or state professional practice restrictions. Users of this database are solely responsible for interactions with any infusion center listed in this database.
Although infusion center data will be updated regularly, you should refer to an individual infusion center's website for the most current information. Infusion center data includes centers that have provided authorization for inclusion in this database.
If you represent an infusion center and would like to be removed from or added to the database, or would like to edit existing information, please send a request by email to firstname.lastname@example.org. Provide the phone number and contact information of the authorized authority of the infusion center that can be contacted to verify the request.
Important Safety Information
- ENTYVIO (vedolizumab) for injection is contraindicated in patients who have had a known serious or severe hypersensitivity reaction to ENTYVIO or any of its excipients.
- Infusion-related reactions and hypersensitivity reactions including anaphylaxis, dyspnea, bronchospasm, urticaria, flushing, rash, and increased blood pressure and heart rate have been reported. These reactions may occur with the first or subsequent infusions and may vary in their time of onset from during infusion or up to several hours post-infusion. If anaphylaxis or other serious infusion-related or hypersensitivity reactions occur, discontinue administration of ENTYVIO immediately and initiate appropriate treatment.
- Patients treated with ENTYVIO are at increased risk for developing infections. Serious infections have been reported in patients treated with ENTYVIO, including anal abscess, sepsis (some fatal), tuberculosis, salmonella sepsis, Listeria meningitis, giardiasis, and cytomegaloviral colitis. ENTYVIO is not recommended in patients with active, severe infections until the infections are controlled. Consider withholding ENTYVIO in patients who develop a severe infection while on treatment with ENTYVIO. Exercise caution in patients with a history of recurring severe infections. Consider screening for tuberculosis (TB) according to the local practice.
- Progressive multifocal leukoencephalopathy (PML), a rare and often fatal opportunistic infection of the central nervous system (CNS), has been reported with systemic immunosuppressants, including another integrin receptor antagonist. PML is caused by the John Cunningham (JC) virus and typically only occurs in patients who are immunocompromised. One case of PML in an ENTYVIO-treated patient with multiple contributory factors has been reported in the post marketing setting (e.g., human immunodeficiency virus [HIV] infection with a CD4 count of 300 cells/mm3 and prior and concomitant immunosuppression). Although unlikely, a risk of PML cannot be ruled out. Monitor patients for any new or worsening neurological signs or symptoms. Typical signs and symptoms associated with PML are diverse, progress over days to weeks, and include progressive weakness on one side of the body or clumsiness of limbs, disturbance of vision, and changes in thinking, memory, and orientation leading to confusion and personality changes. If PML is suspected, withhold dosing with ENTYVIO and refer to a neurologist; if confirmed, discontinue ENTYVIO dosing permanently.
- There have been reports of elevations of transaminase and/or bilirubin in patients receiving ENTYVIO. ENTYVIO should be discontinued in patients with jaundice or other evidence of significant liver injury.
- Prior to initiating treatment with ENTYVIO, all patients should be brought up to date with all immunizations according to current immunization guidelines. Patients receiving ENTYVIO may receive non-live vaccines and may receive live vaccines if the benefits outweigh the risks.
- Most common adverse reactions (incidence ≥3% and ≥1% higher than placebo): nasopharyngitis, headache, arthralgia, nausea, pyrexia, upper respiratory tract infection, fatigue, cough, bronchitis, influenza, back pain, rash, pruritus, sinusitis, oropharyngeal pain, and pain in extremities.
Adult Ulcerative Colitis (UC)
ENTYVIO (vedolizumab) is indicated in adults for the treatment of moderately to severely active UC.
Adult Crohn's Disease (CD)
ENTYVIO (vedolizumab) is indicated in adults for the treatment of moderately to severely active CD.